abstract：:Extracellular vesicles (EVs) are nanovesicles involved in multiple biological functions. Small EVs (sEVs) are emerging as therapeutics and drug delivery systems for their contents, natural carrier properties, and nanoscale size. Despite various clinical application potentials, little is known about the effects of stor...

authors： Wu JY,Li YJ,Hu XB,Huang S,Xiang DX

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Acquired haemophilia A (AHA) is a rare immune-mediated disorder characterised by the development of autoantibodies against factor VIII. Morbidity and mortality are in general high due to multiple factors including the age of the patient, underlying diseases, toxic effects of available treatments and bleeding...

authors： Taher A,Al Mahmasani L,Aadra A,Yazbeck P,Saad GA,Nasr F,Habib R,Chalfoun A,Haddad F

更新日期：2021-12-01 00:00:00

abstract：:Hydrogel serve as bone tissue engineering have lately received great attention for their good biocompatibility and structures similar to natural extracellular matrices. However, a single component polymer hydrogel is generally detrimental to cell adhesion due to the weaker mechanical properties, which limits their app...

authors： Sun QB,Xu CP,Li WQ,Meng QJ,Qu HZ

更新日期：2021-12-01 00:00:00

abstract：:The intracellular pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) exploits host macrophage as a crucial survival and replicative niche. To minimize host immune response stimulated by flagellin, the expression of flagellar genes is downregulated during S. Typhimurium growth within host macrophages. Ho...

authors： Ma S,Jiang L,Wang J,Liu X,Li W,Ma S,Feng L

更新日期：2021-12-01 00:00:00

abstract：:We have applied a recently developed HPLC-MS enzymatic assay to investigate the cryptic peptides generated by the action of the insulin-degrading enzyme (IDE) on some neuropeptides (NPs) involved in the development of tolerance and dependence to opioids. Particularly, the tested NPs are generated from the NPFF precurs...

authors： Wacławczyk D,Silberring J,Grasso G

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:To investigate the role of Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in acute myeloid leukemia (AML) and analyze the potential regulatory network of MALAT1/miR-146a/ CXCR4. METHODS:The expressions of MALAT1, miR-146a and CXCR4 were performed by qRT-PCR and Western Blot. We conducted tr...

authors： Sheng XF,Hong LL,Li H,Huang FY,Wen Q,Zhuang HF

更新日期：2021-12-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are considered as crucial regulatory factors in cancer biology. However, the biological function of long intergenic non-protein coding RNA 960 (LINC00960) in the tumorigenesis of pancreatic ductal adenocarcinoma (PDAC) is still unknown. The goal of this study is to investigate the role o...

authors： Huang Y,Yan Q,Yu D,Sun X,Jiang S,Li W,Jia L

更新日期：2021-12-01 00:00:00

abstract：:Appropriate clearance of dead cells generated by apoptosis is critical to the development of multicellular organisms and tissue homeostasis. In mammals, the removal of apoptotic cell is mediated by polarized monocyte/macrophage populations of the innate immune system. The innate immune system is essential for anti-vir...

authors： Wan J,Yuan L,Jing H,Zheng Q,Xiao H

更新日期：2021-12-01 00:00:00

abstract：:Gastric cancer (GC) is a common malignant gastrointestinal tumor with high mortality. Previous study has reported that the overexpression of lncRNA HCP5 was observed in gastric cancer tissues. The purpose of this study was to investigate the molecular mechanism underlying the effect of lncRNA HCP5 on the proliferative...

authors： Yin D,Lu X

更新日期：2021-12-01 00:00:00

abstract：:The clinical significance and underlying molecular mechanism of miRNA-222-3p in metastatic prostate cancer (MPCa) remain unclear. The present study used a large number of cases (n = 1,502) based on miRNA chip and miRNA sequencing datasets to evaluate the expression and diagnostic potential of miRNA-222-3p in MPCa. We ...

authors： Sun Y,Chen G,He J,Huang ZG,Li SH,Yang YP,Zhong LY,Ji SF,Huang Y,Chen XH,He ML,Wu H

更新日期：2021-12-01 00:00:00

abstract：:In this study, we examined the antitumor effects of Puerarin (PEU) on androgen-independent (DU145 and PC-3) and androgen-dependent (LNCaP) prostate cancer cells, and explored its potential mechanisms. Supplement with PEU (2.5 μM, 5 μM, and 10 μM) exhibited a marked inhibitory effect against the growth of DU145 and PC-...

authors： Li J,Xiong C,Xu P,Luo Q,Zhang R

更新日期：2021-12-01 00:00:00

abstract：:Chitosan hydrolysis by chitosanase is one of the most effective methods to produce chitosan oligosaccharides. One of the prerequisites of enzyme fermentation production is to select and breed enzyme-producing cells with good performance. So in the process of fermentation production, the low yield of chitosanase cannot...

authors： Zhang C,Li Y,Zhang T,Zhao H

更新日期：2021-12-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disease that affects approximately 2% of worldwide population, and causing long-term troubles to the patients. Therefore, it is urgent to develop safe and effective therapeutic drugs. Catalpol is a natural iridoid glucoside, that has several remarkable pharmacological effects, ...

authors： Liu A,Zhang B,Zhao W,Tu Y,Wang Q,Li J

更新日期：2021-12-01 00:00:00

abstract：:Histone lysine specific demethylase 1 (LSD1) has emerged as an attractive molecule target for the discovery of potently anticancer drugs to treat leukaemia. In this study, a series of novel chalcone derivatives were designed, synthesised and evaluated for their inhibitory activities against LSD1 in vitro. Among all th...

authors： Li Y,Sun Y,Zhou Y,Li X,Zhang H,Zhang G

更新日期：2021-12-01 00:00:00

abstract：:SNAP-tag® is a powerful technology for the labelling of protein/enzymes by using benzyl-guanine (BG) derivatives as substrates. Although commercially available or ad hoc produced, their synthesis and purification are necessary, increasing time and costs. To address this limitation, here we suggest a revision of this m...

authors： Merlo R,Caprioglio D,Cillo M,Valenti A,Mattossovich R,Morrone C,Massarotti A,Rossi F,Miggiano R,Leonardi A,Minassi A,Perugino G

更新日期：2021-12-01 00:00:00

abstract：:COVID-19 has resulted in large number of mortalities across the globe. However, Cambodia has recorded low number of COVID-19 cases with no death. A number of factors buttress the accuracy of this phenomenon such as significant support from international health partners, culture of wearing a face mask when sick, timely...

authors： Nit B,Samy AL,Tan SL,Vory S,Lim Y,Nugraha RR,Lin X,Ahmadi A,Lucero-Prisno DE 3rd

更新日期：2021-11-01 00:00:00

abstract：Objective:To study the impact of COVID-19 pandemic lockdown on avoided emergency department visits and consequent hospitalizations. Study design:An observational retrospective design was used to investigate avoided visits and hospitalizations of an departmental emergency department combined with a clustering approach ...

authors： Wartelle A,Mourad-Chehade F,Yalaoui F,Chrusciel J,Laplanche D,Sanchez S

更新日期：2021-11-01 00:00:00

abstract：:A review of recent animal models of Huntington's disease showed many microRNAs had altered expression levels in the striatum and cerebral cortex, and which were mostly downregulated. Among the altered microRNAs were miR-9/9*, miR-29b, miR-124a, miR-132, miR-128, miR-139, miR-122, miR-138, miR-23b, miR-135b, miR-181 (a...

authors： Martinez B,Peplow PV

更新日期：2021-11-01 00:00:00

abstract：:One of the major challenges in emergency medicine is out-of-hospital cardiac arrest (OHCA). Every year, about 53-62/100 000 people worldwide suffer an out-of-hospital cardiac arrest with serious consequences, whereas persistent brain injury is a major cause of morbidity and mortality of those surviving a cardiac arres...

authors： Wolters A,Reuther J,Gude P,Weber T,Theiss C,Vogelsang H,Matschke V

更新日期：2021-11-01 00:00:00

abstract：:Although the transcriptional alterations inside the facial nucleus after facial nerve injury have been well studied, the gene expression changes in the facial nerve trunk after injury are still unknown. In this study, we established an adult rat model of facial nerve crush injury by compressing the right lateral extra...

authors： Cao QQ,Li S,Lu Y,Wu D,Feng W,Shi Y,Zhang LP

更新日期：2021-11-01 00:00:00

abstract：:Nervous system disorders are prevalent health issues that will only continue to increase in frequency as the population ages. Dying-back axonopathy is a hallmark of many neurologic diseases and leads to axonal disconnection from their targets, which in turn leads to functional impairment. During the course of many of ...

authors： Marshall KL,Farah MH

更新日期：2021-10-01 00:00:00

abstract：:Sleep disorders are common in patients with Alzheimer's disease, and can even occur in patients with amnestic mild cognitive impairment, which appears before Alzheimer's disease. Sleep disorders further impair cognitive function and accelerate the accumulation of amyloid-β and tau in patients with Alzheimer's disease....

authors： Kuang H,Zhu YG,Zhou ZF,Yang MW,Hong FF,Yang SL

更新日期：2021-10-01 00:00:00

abstract：:Inflammation and coagulation are tightly interconnected in the pathophysiology of neuronal diseases. Thrombin, a pro-coagulant serine protease is associated with neurodegeneration and its indirect inhibitor, activated protein C (aPC), is considered neuroprotective. While levels of thrombin and aPC activity are readily...

authors： Gerasimov A,Golderman V,Gofrit SG,Aharoni SA,Zohar DN,Itsekson-Hayosh Z,Fay-Karmon T,Hassin-Baer S,Chapman J,Maggio N,Shavit-Stein E

更新日期：2021-10-01 00:00:00

abstract：:The ventral prefrontal cortex (PFC) of primates-a region strongly implicated in decision making-receives highly processed visual sensory inputs from the inferior temporal cortex (ITC) and perirhinal cortex (PRC) and can therefore be considered visual PFC. Usually, the functions of temporal cortex and visual PFC have b...

authors： Eldridge MAG,Hines BE,Murray EA

更新日期：2021-10-01 00:00:00

abstract：:One dominant hypothesis about the function of the orbitofrontal cortex (OFC) is that the OFC signals the subjective values of possible outcomes to other brain areas for learning and decision making. This popular view generally neglects the fact that OFC is not necessary for simple value-based behavior (i.e., when valu...

authors： Zhou J,Gardner MPH,Schoenbaum G

更新日期：2021-10-01 00:00:00

abstract：:In this study, we developed a monoclonal antibody against 2,3',4,5',6-pentabromodiphenylether (BDE-121) using a synthesized hapten, and established an indirect competitive enzyme-linked immunosorbent assay (IC-ELISA), using gold nanoparticles, to amplify the signal. The monoclonal antibody showed high specificity, wit...

authors： Qiao Y,Cai QY

更新日期：2021-10-01 00:00:00

abstract：:In this research, strontium titanate (SrTiO₃), barium titanate (BaTiO₃), barium strontium titanate (BaSrTiO₃), and Ag-doped BaSrTiO₃ nanocomposites with different Ag contents were fabricated using the sol-gel chemical route. The prepared samples were characterized by several techniques including scanning electron micr...

authors： Shirmohammadzadeh L,Moafi HF,Shojaei AF

更新日期：2021-10-01 00:00:00

abstract：:A small aliquot (10-14 μL) of ZnO nanoparticles dispersed in deionized water was deposited by evaporation to produce a dry residue on the working area of a screen-printed electrode. An electrochemical test solution containing K₃Fe(CN)6 and KCl was added to the electrode surface for analysis by electrochemical impenden...

authors： Wang K,Zhang W,Lai EPC

更新日期：2021-10-01 00:00:00

abstract：:Waste toner powders are considered as hazardous materials to human and living things, and should be properly recycled by many effective ways due to their fine particle sizes and complex components. In this paper, waste toner powders were used as raw materials to successfully synthesize three dimensions (3D) graphene o...

authors： Tian Z,Sun L,Tian H,Cao K,Bai S,Li J,Zhu Q

更新日期：2021-10-01 00:00:00

abstract：:Carbon doped silver/iron/TiO₂ nanocomposite is synthesized via the solvothermal technique. Titanium tetraisopropoxide is used as a TiO₂ source. The composite samples are characterized by different physicochemical methods, including nitrogen adsorption-desorption analysis, transmission electron microscope, scanning ele...

authors： Chauhan N,Singh V,Kumar S,Kumari M

更新日期：2021-10-01 00:00:00

abstract：:In this research article, we introduced an algorithm to evaluate COVID-19 patients admission in hospitals at source shortage period. Many researchers have expressed their conclusions from different perspectives on various factors such as spatial changes, climate risks, preparedness, blood type, age and comorbidities t...

authors： Geetha S,Narayanamoorthy S,Manirathinam T,Kang D

更新日期：2021-09-15 00:00:00

abstract：:Due to the current COVID-19 pandemic, much effort has been put on studying the spread of infectious diseases to propose more adequate health politics. The most effective surveillance system consists of doing massive tests. Nonetheless, many countries cannot afford this class of health campaigns due to limited resource...

authors： Martínez-Guerra R,Flores-Flores JP

更新日期：2021-09-15 00:00:00

abstract：:Corona Virus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome coronavirus (SARS CoV-2) has been declared a worldwide pandemic by WHO recently. The complete understanding of the complex genomic structure of SARS CoV-2 has enabled the use of computational tools in search of SARS CoV-2 inhibitors again...

authors： Gajjar ND,Dhameliya TM,Shah GB

更新日期：2021-09-05 00:00:00

abstract：Introduction:In the COVID 19 pandemic, pituitary surgery is one of challenging surgical treatment, especially the involving transsphenoid approach. It was reported that the aerosolisation and mucosal involvement increase the risk of viral transmission during operation. Therefore, transcranial is a safer surgical approa...

authors： Golden N,Niryana W,Awyono S,Mardhika PE,Putra MB,Biondi MS

更新日期：2021-09-01 00:00:00

abstract：Background:Traditional medicine (TM) is widely used in South Korea and Taiwan, and both societies have similar systems for the management of TM. This study aimed to compare the TM systems in South Korea and Taiwan. Methods:We searched for studies on the TM systems and collected statistical data from the websites of re...

authors： Kim D,Shih CC,Cheng HC,Kwon SH,Kim H,Lim B

更新日期：2021-09-01 00:00:00

abstract：Background:Pattern diagnosis-guided treatments in Traditional Chinese Medicine (TCM) has been recognised by the eleventh revision of the International Classification of Diseases (ICD-11). Accurate pattern diagnosis requires reliable and valid diagnostic instruments that guide the collection of TCM clinical data without...

authors： Ho LT,Chung VC,Wong CH,Wu IX,Lan KC,Wu D,Yeung JW,Zhang NL,Leung TH,Wu JC

更新日期：2021-09-01 00:00:00

abstract：:With the development of thick-film paste, silver and copper are circulating in the market as the electric conductive fillings currently. Unfortunately, the cost of silver is exceedingly high, while the copper has to be sintered in the reducing atmosphere. In this study, we proposed to exert aluminum as the filling due...

authors： Chuang KC,Lee WH

更新日期：2021-09-01 00:00:00

abstract：:In this study, we designed and synthesized two blue fluorescence materials using 7,7-dimethyl-9-(10-phenylanthracen-9-yl)-7H-benzo[b]fluoreno[3,4-d]thiophene substituted anthracene derivatives. To characterize their electroluminescent properties, we fabricated the OLED devices using these two emitting materials. Parti...

authors： Lee JH,Han GW,Kim KJ,Lee H,Kim YK,Yoon SS

更新日期：2021-09-01 00:00:00

abstract：:With the development of thick-film paste, silver and copper are circulating in the market as the electric conductive fillings currently. Unfortunately, the cost of silver is exceedingly high, while the copper has to be sintered in the reducing atmosphere. In this study, we proposed to exert aluminum as the filling due...

authors： Chuang KC,Lee WH

更新日期：2021-09-01 00:00:00

abstract：:The presence of malachite green dye in wastewater has a great negative impact on the environment. At present, industrial wastewater is treated using adsorption, electrolysis and membrane separation, among which the adsorption method is the most widely used wastewater treatment. In this study mesoporous silica nanopart...

authors： Xiao XQ,Chen ZY,Chen JW,Chen QH

更新日期：2021-09-01 00:00:00